LIFE EXTENSION MAGAZINE
By Chancellor Faloon
The Mediterranean diet consists of a low intake of red meat and sweets with greater emphasis on fish, vegetables, mixed nuts, whole grains, wine (moderate consumption), and olive oil.4,5
Unrefined extra virgin olive oil, a chief component of the Mediterranean diet, has been given significant credit for the diet’s health-promoting ability, especially with its rich polyphenol content.6-9
Today, substantial new findings further validate extra virgin olive oil’s benefits for cardiovascular, bone, and brain health. Several of these studies were large-scale clinical trials on humans.
One study in particular caught mainstream media attention. This study, with nearly 19,000 participants, showed that those who consumed the highest quality foods, and who most closely adhered to a true Mediterranean diet, were the ones who were most likely to derive the benefits, including sharp reductions in coronary heart disease and stroke.10
In a study conducted in Italy, almost 19,000 people were assessed to determine their adherence to a Mediterranean-style diet. The researchers discovered that people who derived the greatest health benefits ingested higher concentrations of micronutrients such as polyphenols.
One of the greatest sources of polyphenols in the Mediterranean diet stems from extra virgin olive oil. Olive oil that is not extra virgin is commercially produced in a way that degrades the polyphenols.8,11,12
In addition, a large quantity of supposed extra virgin olive oil is counterfeit and does not meet the legal grades to be considered extra virgin. These counterfeit oils have even been refined and adulterated with pro-inflammatory fats such as corn, safflower, and sunflower oils. It is estimated that this is the case in 50% of the extra virgin olive oil sold in Italy, which implies that greater health benefits could be attained if purveyors of counterfeit olive oil were stopped.13-15
The situation is even worse in America, where an estimated 80% of extra virgin olive oil does not meet the legal grades to be called extra virgin.13 Producing top-quality olive oil takes time and care, and there are many unscrupulous providers that intentionally mislabel their product to make money.
The lead author of the Italian study on Mediterranean diet quality suggested that testing for levels of polyphenols and other diet-derived natural compounds would be the ideal way to confirm the importance of this quality.16
Polyphenol Concentrations Show Connection With Olive Oil’s Benefits
The high oleic acid (monounsaturated fat) content of olives was initially thought to be the main source of olive oil’s health benefits.17 Today, more researchers contend that the health benefits stem from olive oil’s high polyphenol content which includes: oleuropein, tyrosol, and hydroxytyrosol.18-20
Increasing evidence suggests that the polyphenol hydroxytyrosol should be given the most credit as it makes up approximately 50% of extra virgin olive oil’s total polyphenol content.19
In 2017, the American Journal of Clinical Nutrition published a study that evaluated the effects of hydroxytyrosol on a cohort of 1,851 men and women.21
To be eligible for this study all participants had to be at high-risk for cardiovascular disease.
The participants averaged age 67 and had either type II diabetes or at least three or more major risk factors: smoking, hypertension, dyslipidemia, overweight/obesity, or a family history of premature cardiovascular disease.
The subjects were divided randomly into one of three different intervention groups:
- Group 1: Traditional Mediterranean diet supplemented with extra virgin olive oil.
- Group 2: Traditional Mediterranean diet supplemented with nuts.
- Group 3: Control, low-fat diet.
To measure hydroxytyrosol ingestion, urinary levels of its metabolite (homovanillyl alcohol) were measured.
Results showed that higher urinary levels of homovanillyl alcohol resulted in sharply lower risks of cardiovascular events and mortality.21
Compared to those in the lowest quintile, individuals in the third or higher quintile levels of homovanillyl alcohol had at least 56% reduced risk of a cardiovascular event (heart attack, stroke, or death from cardiovascular cause). In addition, subjects in the highest quintile of homovanillyl alcohol had, on average, 9.5 years longer life after the age of 65.21
The highest urinary levels of homovanillyl alcohol were obtained by the subjects whose intervention included a traditional Mediterranean diet with the addition of extra virgin olive oil.
WHAT YOU NEED TO KNOW
Extra Virgin Olive Oil for Heart, Bone, and Brain Health
- Extra virgin olive oil is a key component of the Mediterranean diet.
- A recent Italian study discusses the necessity of eating high quality, polyphenol-rich foods in order to obtain the benefits we associate with a Mediterranean diet.
- Oleuropein, tyrosol, and hydroxytyrosol are important polyphenols found in high-quality extra virgin olive oil.
- A Mediterranean diet rich in high-quality extra virgin olive oil is linked with reduced risks of cardiovascular disease and low bone density, and recent animal research has provided insights on its importance in fighting neurodegenerative diseases like Alzheimer’s.
Olive Oil Alzheimer’s Study Reaches Mainstream Media
Research on olive oil has been primarily focused on its cardiovascular support. However, a growing amount of research in the last decade has shown that it also reduces the risk of Alzheimer’s disease.22-24
In a revealing animal study, researchers examined the effects of extra virgin olive oil on mice genetically prone to develop neurodegenerative changes typical of Alzheimer’s disease, such as a myloid plaque. These six-month-old mice were divided into two groups, one fed a standard diet, and the other group the same standard diet plus extra virgin olive oil. After six months, they found significant differences in their behavior and neuropathology. The researchers concluded that extra virgin olive oil exerted a beneficial effect on all major characteristics of Alzheimer’s disease, including behavior and neuropathology.25
To test their neuropathology, all major biomarkers for Alzheimer’s disease (beta-amyloid, tau proteins, and synaptophysin) were recorded.26
Beta-amyloid and tau are deleterious proteins that, through many mechanisms, cause cellular dysfunction and death. Synaptophysin is a protein marker of synaptic integrity.
The research found that in the mice fed extra virgin olive oil, there was a significant decrease in these deleterious proteins and an increase in the beneficial synaptophysin.25
The researchers credited these beneficial effects to extra virgin olive oil’s ability to increase autophagy.
Autophagy is how cells rid themselves of debris that interferes with normal healthy cellular function.
This study, conducted by researchers at Temple University, was significant enough to catch media attention in USA Today.27
Olive Oil and Bone Health
A fracture in the hip has a higher mortality rate than all other fractures in the elderly. The incidence of hip fractures are increasing yearly by 1%–3% in most regions of the world.28
A meta-analysis of three studies revealed that adherence to the Mediterranean diet was associated with a 21% reduced risk of hip fractures.29
In an additional study, a key component of the Mediterranean diet, extra virgin olive oil, was tested against a diet high in nuts, or a low-fat diet, on 870 subjects ages 55-80 with high risk of cardiovascular disease.30 The subjects were monitored over a median follow-up of 8.9 years, during which 114 cases of osteoporosis-related fractures occurred.
Subjects who integrated the highest amounts of extra virgin olive oil into their diet had a 51% lower risk of fracture.30
The most common way to assess the risk of fracture is a bone densitometry study, which is a specialized type of X-ray. These tests generate a “T-score” – higher T-scores mean greater bone-mineral density, and lower risk of fracture.
In another study on bone density, a group of researchers determined the T-scores of 418 subjects, average age of 50, and compared their diets.31
The researchers found the highest T-scores directly corresponded to those who had the greatest adherence to the Mediterranean diet, while the lowest T-scores were found in individuals who had the highest consumption of red meat. The foods items most closely correlated with high T-scores were extra virgin olive oil, fish, and fruits.31
Olive oil’s bone-health supporting potential has also been demonstrated in animal studies. In one study, rats were assigned to one of four diet regimens. All received a regular diet, but with fat from either virgin olive oil or sunflower oil, which is high in omega-6 fatty acids. Two additional groups received supplemental CoQ10 in addition to olive or sunflower oil.32
In aged rats (24 months old), loss of bone mineral density was significantly greater in sunflower oil-fed rats compared to the group that received olive oil. Interestingly, bone-mineral density and concentration was markedly increased, in both diet groups when supplemented with CoQ10.
The researchers found that sunflower oil was associated with significantly greater oxidative stress, which was effectively controlled with CoQ10 supplementation.
Additional Benefits of the Mediterranean Diet and Extra Virgin Olive Oil
In a double-blind placebo-controlled study on 41 adult women, extra virgin olive oil was able to increase the weight loss effect of an energy restricted diet. A control group of 20women was selected to eat a daily high-fat breakfast with added soybean oil, and an intervention group of 21 women received a high-fat breakfast with the addition of extra virgin olive oil.33
After nine weeks, the average weight loss in the 21 women that received the breakfast with extra virgin olive oil was approximately 80% higher than the control group. Diastolic blood pressure decreased by an average of 5.1 mmHg, and pro-inflammatory cytokines were also reduced in the group that received extra virgin olive oil.33
In another recent study, researchers compared a Mediterranean diet to an average Australian diet for their impacts on metabolic and cardiovascular risk biomarkers.34 The study included 152 participants, age 65 or greater. The Mediterranean diet was followed by 80 participants and 72 participants followed the average Australian diet. After 6 months, a significant reduction in F2-isoprostanes and triglycerides was seen in the participants who followed the Mediterranean diet.34
F2-isoprostanes are produced by the reaction of free radicals with arachidonic acid.35 It is an under-utilized marker for oxidative stress. An innovative study found that the odds of coronary heart disease in individuals with the highest levels were elevated up to 30-fold compared to those with normal levels.36
Triglycerides were long ago shown to increase vascular disease risk when elevated.
The blood marker most commonly evaluated for coronary artery disease risk is LDL cholesterol. The majority of the cardiovascular damage caused by LDL comes from its oxidized form.37,38 In a study of 71 subjects, a year-long Mediterranean diet intervention enriched with extra virgin olive oil was able to increase LDL’s resistance to oxidation by 6.46% and decrease the degree of LDL oxidative damage by 36.3%.39
A growing amount of research shows that extra virgin olive oil and adherence to a Mediterranean diet dramatically reduces stroke and heart attack risk.
Those who ingest the highest amount of an olive polyphenol called hydroxytyrosol were shown to live 9.5 years longer (after age 65). These findings were published in 2017.21
These recent discoveries corroborate research uncovered by Life Extension® in 2005.40 Many readers of this magazine have used this data to supplement with nutrient formulas containing olive polyphenols and/or increase their dietary intake of extra virgin olive oil.
- Kok FJ, Kromhout D. Atherosclerosis–epidemiological studies on the health effects of a Mediterranean diet. Eur J Nutr. 2004;43 Suppl 1:I/2-5.
- Henriquez Sanchez P, Ruano C, de Irala J, et al. Adherence to the Mediterranean diet and quality of life in the SUN Project. Eur J Clin Nutr. 2012;66(3):360-8.
- Veronese N, Stubbs B, Noale M, et al. Adherence to the Mediterranean diet is associated with better quality of life: data from the Osteoarthritis Initiative. Am J Clin Nutr. 2016;104(5):1403-9.
- Willett WC. The Mediterranean diet: science and practice. Public Health Nutr. 2006;9(1a):105-10.
- Widmer RJ, Flammer AJ, Lerman LO, et al. The Mediterranean diet, its components, and cardiovascular disease. Am J Med. 2015;128(3):229-38.
- Schwingshackl L, Hoffmann G. Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies. Lipids Health Dis. 2014;13:154.
- Buckland G, Mayen AL, Agudo A, et al. Olive oil intake and mortality within the Spanish population (EPIC-Spain). Am J Clin Nutr. 2012;96(1):142-9.
- Rigacci S, Stefani M. Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans. Int J Mol Sci. 2016;17(6).
- Available at: http://www.predimed.es/introduction.html. Accessed October 18, 2017.
- Bonaccio M, Di Castelnuovo A, Pounis G, et al. High adherence to the Mediterranean diet is associated with cardiovascular protection in higher but not in lower socioeconomic groups: prospective findings from the Moli-sani study. International Journal of Epidemiology. 2017.
- Owen RW, Mier W, Giacosa A, et al. Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene. Food Chem Toxicol. 2000;38(8):647-59.
- Hoffman R, Gerber M. Food Processing and the Mediterranean Diet. Nutrients. 2015;7(9):7925-64.
- Available at: http://www.cbsnews.com/news/60-minutes-overtime-how-to-buy-olive-oil/. Accessed October 9, 2017.
- Available at: http://www.forbes.com/sites/ceciliarodriguez/2016/02/10/the-olive-oil-scam-if-80-is-fake-why-do-you-keep-buying-it/#2927ff125e0c. Accessed October 9, 2017.
- Available at: http://www.oliveoiltimes.com/olive-oil-basics/mafia-olive-oil-on-60-minutes/50203. Accessed October 9, 2017.
- Available at: http://www.cnn.com/2017/07/31/health/mediterranean-diet-heart-benefits-socioeconomic-study/index.html. Accessed October 9, 2017.
- Visioli F, Galli C. Olive oil: more than just oleic acid. Am J Clin Nutr. 2000;72(3):853.
- Tripoli E, Giammanco M, Tabacchi G, et al. The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health. Nutr Res Rev. 2005;18(1):98-112.
- Tejada S, Pinya S, Del Mar Bibiloni M, et al. Cardioprotective effects of the polyphenol hydroxytyrosol from olive oil. Curr Drug Targets. 2016.
- Virruso C, Accardi G, Colonna-Romano G, et al. Nutraceutical properties of extra-virgin olive oil: a natural remedy for age-related disease? Rejuvenation Res. 2014;17(2):217-20.
- De la Torre R, Corella D, Castaner O, et al. Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylathion. Am J Clin Nutr.2017;105(6):1297-304.
- Aridi YS, Walker JL, Wright ORL. The Association between the Mediterranean Dietary Pattern and Cognitive Health: A Systematic Review. Nutrients. 2017;9(7).
- Abuznait AH, Qosa H, Busnena BA, et al. Olive-oil-derived oleocanthal enhances beta-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: in vitro and in vivo studies. ACS Chem Neurosci. 2013;4(6):973-82.
- Casamenti F, Stefani M. Olive polyphenols: new promising agents to combat aging-associated neurodegeneration. Expert Rev Neurother. 2017;17(4):345-58.
- Lauretti E, Iuliano L, Pratico D. Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy. Ann Clin Transl Neurol. 2017;4(8):564-74.
- Bloom GS. Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol.2014;71(4):505-8.
- Available at: https://www.usatoday.com/story/news/nation-now/2017/06/21/extra-virgin-olive-oil-staves-off-alzheimers-preserves-memory-new-study-shows/415279001/. Accessed October 10, 2017.
- Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet.2002;359(9319):1761-7.
- Malmir H, Saneei P, Larijani B, et al. Adherence to Mediterranean diet in relation to bone mineral density and risk of fracture: a systematic review and meta-analysis of observational studies. Eur J Nutr. 2017.
- Garcia-Gavilan JF, Bullo M, Canudas S, et al. Extra virgin olive oil consumption reduces the risk of osteoporotic fractures in the PREDIMED trial. Clin Nutr. 2017.
- Savanelli MC, Barrea L, Macchia PE, et al. Preliminary results demonstrating the impact of Mediterranean diet on bone health. J Transl Med. 2017;15(1):81.
- Varela-Lopez A, Ochoa JJ, Llamas-Elvira JM, et al. Loss of Bone Mineral Density Associated with Age in Male Rats Fed on Sunflower Oil Is Avoided by Virgin Olive Oil Intake or Coenzyme Q Supplementation. Int J Mol Sci. 2017;18(7).
- Galvao Candido F, Xavier Valente F, da Silva LE, et al. Consumption of extra virgin olive oil improves body composition and blood pressure in women with excess body fat: a randomized, double-blinded, placebo-controlled clinical trial. Eur J Nutr. 2017.
- Davis CR, Bryan J, Hodgson JM, et al. A Mediterranean Diet Reduces F2-Isoprostanes and Triglycerides among Older Australian Men and Women after 6 Months. J Nutr. 2017;147(7):1348-55.
- Roberts LJ, Morrow JD. Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med. 2000;28(4):505-13.
- Schwedhelm E, Bartling A, Lenzen H, et al. Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control study. Circulation. 2004;109(7):843-8.
- Ehara S, Ueda M, Naruko T, et al. Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation. 2001;103(15):1955-60.
- Gao S, Liu J. Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease. Chronic Diseases and Translational Medicine. 2017;3(2):89-94.
- Hernaez A, Castaner O, Goday A, et al. The Mediterranean Diet decreases LDL atherogenicity in high cardiovascular risk individuals: a randomized controlled trial. Mol Nutr Food Res. 2017;61(9).
- Available at: http://www.lifeextension.com/Magazine/2005/1/report_multi/Page-01. Accessed November 6, 2017.